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Conclusions The development of incretin-based treatments has helped improve the quality of life and the management of symptoms for patients inflicted with T2DM

*Correspondence: Dirin Ukwade [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Other significant advantages of this method are shorter reaction time, excellent yield, simple work-up procedure, easy catalyst handling, and the high stability of the catalyst, which renders the protocol economic and sustainable.

Caffeine is a mild diuretic, so compensate with extra water intake

In conclusion, this is the first study to show that NRTP can impair ovarian function through multiple pathways (fibrosis, PMF overactivation, and inflammation)