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2012 , 709893 (2012) Mann, R

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What to know about the new era of GLP-1 drugs After revolutionizing care for diabetes and weight loss, GLP-1 drugs are being eyed for more

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In contrast, multiple rodent pulmonary hypertension models demonstrate that GLP-1 receptor agonists, including exendin-4 and liraglutide, reduce vascular remodelling, inflammation, and ventricular hypertrophy via endothelial nitric oxide signalling and suppression of endothelin-1 pathways [68,69,72,73]