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Leisegang K, Sengupta P, Agarwal A, Henkel R

As OTS964 treatment results not only in SF3B1 dephosphorylation, but also in stalling of spliceosome in B OTS964 intermediate, it is very likely that conformational change of the spliceosome itself also contributes to the observed decrease of P-SF3B1 binding to the ISL in U6 snRNA and we cannot distinguish between these two scenarios

That can delay appropriate care and create false confidence

How much of the historical clinical benefit attributed to extracts reflects the peptides themselves versus non-specific or placebo effects in unblinded designs

3-O-Ethyl is oil-soluble and stable