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Third, the small number of events does not allow us to detect a potentially significant difference in the beneficial effect between GLP-1 RA and SGLT-2i or among single agents of the same class of drugs

Contraindications include a personal or family history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome type 2 (MEN 2), or a known allergic reaction to the medication

This happens largely because appetite returns to previous levels, and the metabolic improvements gained during treatment are no longer present

Randomized trials in non-GLP-1 populations show that reducing carbohydrate fermentation lowers breath hydrogen and gas-related symptoms, supporting this mechanism., Plain-English explanation why carbs sit longer and make more gas In simple terms, slower digestion gives gut bacteria more time to work on carbohydrates