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Finally, a cell cycle-dependent variation of the amount of GSTP1-1-TRAF2 complex existing in cells was detected, with a maximum in G 0 /G 1 and a strong decrease in S, G 2 , and M phases

These findings collectively validate that precise intervention in this axis may markedly augment chemotherapeutic efficacy, though the successful clinical translation of such combinations require careful patient stratification based on molecular and histological subtypes

Since there is little knowledge of how efficiently the peptide crosses the blood brain barrier when administered parenterally, an intranasal delivery route was selected for this study

Electrolyte balance matters alongside hydration

Indeed, LAT1/SLC7A5 expression has been reported to be increased in several cancer types [13,14]