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5.2 Pharmacotherapy Targeting Pathogenesis Alpha-Lipoic Acid Since oxidative stress plays a significant role in the pathogenesis of DPN, attention has been focused on antioxidants such as alpha-lipoic acid (ALA) as potential treatments

The mechanistic literature is quite clear that the rate-limiting resource is the sulfur amino-acid supply, not the intact tripeptide, which is why so much of the classical work focused on precursor delivery rather than on feeding animals glutathione itself

Because glutathione is a protein (a tripeptide), the stomach often breaks it back down into its individual amino acids before it ever reaches your cells

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Glutathione Peroxidase 4 Differentially Regulates the Release of Apoptogenic Proteins from Mitochondria Rains, J.L., & Jain, S.K