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Betaine is utilised in most tissues as an osmoproctectant in addition to its primary role as a methyl group donor in liver metabolism (reviewed by Zhao et al, 2018)

& Bevan, J

Extensive research efforts have been made to identify approaches to effectively deliver medication to the brain

189 Additionally, the absence of N6-methyladenosine modification results in high expression of cyclin-dependent kinase 1 (CDK1) in oxaliplatin-resistant colon cancer cells and tissues