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Patients experiencing severe or persistent side effects should contact their provider

doi: 10.1523/jneurosci.3344-05.2006 12 BennettS

The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]