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[oai_citation:1PubMed]( 2) Nitric-oxidemediated, largely endothelium-dependent vasorelaxation Aortic ring experiments showed vasodilation that was blunted by L-NAME and hemoglobin and attenuated without endotheliumconsistent with NO-mediated effects

The choice between a localized or systemic approach should be dictated entirely by the objective of your research study

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Adequate hydration supports peptide distribution and cellular processes

Any expectation of results should be calibrated accordingly