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Animal experiments in this study were performed in accordance with Yokohama City University Institutional Animal Care and Use Committee guidelines and with ARRIVE guidelines ( All animal experiments were approved by the Institutional Committee of Laboratory Animal Experimentation (Animal Research Center of Yokohama City University, Yokohama, Japan)

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The real market question may not be just about efficacy but how patients, prescribers, and payers weigh the trade-off between stronger outcomes, side-effect tolerability, and affordability