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Mitochondria also host antioxidant enzymes such as superoxide dismutase (SOD) and catalase as the first line of defense against ROS by converting superoxide to H 2 O 2 and subsequently to water

Summary Keywords Pycnogenol , procyanidins, bioavailability, distribution, metabolism, elimination, pharmacokinetics Citation Bayer J and Hgger P (2024) Review of the pharmacokinetics of French maritime pine bark extract (Pycnogenol ) in humans

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Fang X, Ardehali H, Min J, Wang F

Sublingual administration of the extract significantly increased blood flow in both normal and ischemic conditions without altering systemic blood pressure or intraocular pressure, suggesting localized vascular effects