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Endogenous GLP-1 levels have been shown to be lower in the follicular phase compared with the luteal phase ( Concomitant use of GLP-1 and estradiol conjugates has been primarily limited by the oncogenic and gynecological side-effects that have been attributed to estrogens

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20 Preclinical evidence suggests estradiol (the most active type of human estrogen) supports normal fat metabolism, suppresses fat production and accumulation in the liver, reduces inflammatory signaling in the liver, and inhibits liver fibrosis

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Men with MOSI have no underlying cause of infertility other than markers of oxidative stress in their semen analysis