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doi: 10.1007/s00280-015-2716-9, 23

With the same VYVANSE dose, mean steady state exposure of dextroamphetamine was approximately 44% higher in pediatric patients ages 4 to 5 years compared to the pediatric patients ages 6 to 11 years

Data from human and animal studies provide strong evidence of neurovascular unit dysfunction with BBB hyperpermeability in association with oxidative stress and neuroinflammation (118), which can increase the susceptibility to neurological disorders such as depression

About 60% of the dose is eliminated via urine, less than 1% is excreted unchanged and the rest is eliminated through the bile in the feces modified

Pre-analytical factors significantly affect results