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488,489,490 In the pancreas, this stimulates the secretion of insulin and inhibits the secretion of glucagon

Type 2 diabetes develops when the body becomes resistant to insulin and the pancreas gradually loses its ability to produce enough insulin to overcome that resistance

Amylin, released with insulin from beta cells in the pancreas, induces its satiating effect via both the homoeostatic and hedonic regions of the brain

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Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice