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The absolute risk per patient remains modest, but the very large and growing number of people on these medications means the absolute number of patients presenting with biliary complications is substantial and rising

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Mitochondrial respiration and fatty-acid oxidation Cell and mouse studies reported increased mitochondrial respiration, oxygen consumption, oxidative muscle features, fatty-acid oxidation, and resting energy expenditure

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Older adults are at higher risk of muscle wasting (sarcopenia)