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Things like step-down dosing or pairing these drugs with lifestyle support might be part of the solution, but the research is scant

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2.6 Probiotics and gut microbiota modulation The human gut microbiome has rapidly emerged as a critical and modifiable cancer susceptibility, treatment-response, and survivorship determinant, including in breast cancer where the paradigm has attracted attention to probiotics and gut-microbiota targeting as promising adjunctive strategies (174)