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The research on MOTS-c dosage has matured considerably since the original mouse studies, though human clinical trials remain limited in number

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Moderately reduced ATP levels promote oxidative stress and debilitate autophagic and phagocytic capacities in human RPE cells

Abstract The paradigm of one drug against multiple targets, known as unimolecular polypharmacology, offers the potential to improve efficacy while overcoming some adverse events associated with the treatment