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The sub-protective concentration range will likely occur several weeks or months following mAb administration, when much of the initial drug dose has cleared the body

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Damit eine therapeutisch nutzbare Glutathion-Therapie in therapeutisch wirksamen und vertretbaren intrazellulren Konzentrationen ber unterschiedliche Applikationswege (oral-enteral, nasal, buccal, sublingual, per inhalationem, vaginal, rektal, intracutan, subcutan, intramuskulr, intravens, per infusionem, intraarteriell) mglich ist,mu das Molekl mit intakter SH-Gruppe intrazellulr zur Wirkung kommen knnen und gut membrangngig sein.So that therapeutically usable glutathione therapy in therapeutically effective and justifiable intracellular concentrations is possible via different application routes (oral-enteral, nasal, buccal, sublingual, by inhalation, vaginal, rectal, intracutaneous, subcutaneous, intramuscular, intravenous, by infusion, intra-arterial) , the molecule with an intact SH group must be able to take effect intracellularly and be well membrane-permeable

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However, not all xenobiotics (including drugs) are conjugated/inactivated by this pathway ( The mercapturic acid pathway ( Figure 1 ) involves the conjugation of the tripeptide, GSH, to xenobiotics (including drugs) to render them more hydrophilic and facilitate their elimination