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Peak appetite suppression, the strongest reduction in hunger and food-related thinking, typically occurs around weeks 12 to 14 at therapeutic doses

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While significant breakthroughs have been achieved in multimodal modulation of mitochondrial biogenesis, mitophagy, and dynamics, persisting challenges include incomplete elucidation of molecular regulatory networks and genetic foundations, limitations of single-pathway intervention strategies in achieving multi-target coordination, and technical barriers imposed by the selective permeability of the blood-brain barrier (BBB) that hinder clinical translation of mitochondrial-targeted therapies (Meng et al., 2024)

This finding was replicated in nonhuman primates using another antibody, now against the human GIP receptor, supportive of an antagonistic approach for obesity treatment (54)