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This is particularly important for oral contraceptives, where the MHRA advises using a non-oral contraceptive method or adding a barrier method for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase

Itchy skin is not a primary or frequently reported adverse effect in tirzepatide clinical trials, but isolated cases have been documented in real-world use

Bloating and gas These are common companions to the other gastrointestinal symptoms and are related to the same slowing of digestive transit

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