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Because these are distinct satiety circuits, the hypothesis is that combining them could produce additive appetite suppression rather than simply doubling a single mechanism

In addition, the chronic expression of the vector protein S gene, in individuals carrying certain HLA haplotypes, could induce immune hyperactivation and excessive production of proinflammatory cytokines, leading to autoimmune hypophysitis or inhibition of ACTH secretion (functional hypopituitarism) (62)

Glucagon-like peptide-1 receptor agonists significantly increased gastric emptying T , with a large effect size (standardized mean difference, 2.38

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2015;33(1 Suppl 88):S825