Advanced Science (2024) 10
The heart, in fact, can tolerate a large number of aberrant electrical signals which is what arrhythmias are without being damaged by them in the least
Overactivity of astroglial A 2A R induces extrasynaptic and postsynaptic mGluR1 and mGluR5 coupling to Gq protein (G protein subunit, which activates phospholipase and thereby increases diacylglycerol and inositol-triphosphate levels) by enhancing astroglial glutamate release, which can further increase intracellular calcium levels and lead to inhibition of D 2 R signaling in A 2A R-D 2 R and A 2A R-mGluR5 complexes (Figure 1) [37]

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