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402 Currently, the hypothesis of cortical E/I imbalance in autism is widely accepted (Fig

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Cartilage destruction is considered a hallmark of OA and is a result of increased production of catabolic effectors 32,33,34,35 and reduced matrix biosynthesis by chondrocytes 36

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All of this activity requires a significant amount of energy and oxygen, which naturally leads to the production of reactive oxygen species, or free radicals

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So the weight-loss demand that drives the 50-64 peak largely disappears at 65, when private insurance gives way to Medicare

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