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The results of in vitro measurements using pQCT and Archimedes principle, in addition to ash weight determinations, show that the increases in cortical and total BMC were due to an increased growth of the bones with increased bone dimensions, whereas the volumetric BMD [bone mineral density] was unchanged. This also holds true when bone formation is purposefully inhibited by a bone-catabolizing compound such as methylprednisolone: the periosteal bone formation rate increased four-fold in animals injected with [methylprednisolone] and [Ipamorelin] in combination, compared with the group injected with [methylprednisolone] alone

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