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Similarly, weight-related metabolic measurements for blood pressure, triglycerides, HDL (good cholesterol) and HbA1c (a measure for diabetes risk) held steady at their best levels or even improved following the reduction in dose frequency

Consistent with these observations, animal models with iHSP72 overexpression exhibit improved insulin sensitivity and reduced systemic inflammation, reinforcing its therapeutic relevance

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Zermati Y, Garrido C, Amsellem S, Fishelson S, Bouscary D, Valensi F, et al

In the phase 3 ARISE (Acid Lipase Replacement Investigating Safety and Efficacy) trial, sebelipase alfa was evaluated in a randomized, double-blind, placebo-controlled trial in 66 children and adults with LAL-D