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Ramzan R, Dolga AM, Michels S, Weber P, Culmsee C, Rastan AJ

High levels of catecholamine metabolism in the midbrain are associated with increased levels of neuromelanin in the same region and, it is neuromelanin that is thought to be one of the molecules responsible for inducing chronic neuroinflammation in PD

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The 2026 clinical consensus confirms that these safety profiles are well-understood, especially as patients transition to FDA-approved formulations like the newer oral Wegovy or the high-dose 7.2 mg Wegovy HD

Wong WT, Kam W, Cunningham D, Harrington M, Hammel K, Meyerle CB, Cukras C, Chew EY, Sadda SR, Ferris FL