semaglutide lowers blood pressure via GLP-1 receptors on vascular smooth muscle, not via endothelial or immune pathways. There is a direct vasorelaxant mechanism linking GLP-1R activation to BP and… Semaglutide's Role in Arterial Stiffness

The duration of treatment may also play a role, with some evidence suggesting that longer treatment periods may be associated with better weight maintenance, though this relationship is not definitively established

But the authors appropriately noted limitations: the retrospective design, small sample size, and the fact that most patients were already in remission when starting therapy

for instance, in the SCALE Obesity and Prediabetes study liraglutide induced a mean weight loss of 8.4 kg with a standard deviation of 7.3 kg 111

Start with a low daily dose

Many people see better blood sugar control, improved insulin sensitivity, and healthier triglycerides