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In addition, despite continuous discussions about affordability, insurers are progressively expanding reimbursement coverage, increasing the accessibility of these treatments

Older people with severe kidney disease (who are not on dialysis) are an exception to this rule these individuals may need to limit their protein intake, as their kidneys may not be able to properly process the protein

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In humans, OCT1 is mainly expressed in the sinusoid membrane of hepatocytes, whereas in rodents, OCT1 is strongly expressed in the basolateral membrane of renal proximal tubule cells

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