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The translational squeeze the number of products that begin rodent trials compared to the number that successfully progress from rodent trials to human trials, and from human trials to regulatory approval is estimated to be greater than 20 to one

However, significant physiological differences between species must be considered when interpreting veterinary data for human clinical applications

249,250 Acute systemic injections of the bacterial antigen lipopolysaccharide (LPS) in mice induces diffuse inflammatory changes in the CNS and mimics this sickness behaviour and is often used as a model to study effects of inflammation on CNS functions

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