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No adverse events were reported in either study, but the small number of participants makes it difficult to draw broader conclusions

PMID: 34459213 DOI: 10.1161/CIRCULATIONAHA.121.056824 Packer M et al (2022): Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis