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Although PYC has been shown to reduce CRP levels, existing trials are limited by small sample sizes (e.g., five studies totaling approximately 324 participants in a CRP meta-analysis), high heterogeneity (I 2 99%), and variability in dosing regimens, treatment duration, and study populations ( Similarly, although PYCs anticancer effects have been demonstrated in multiple cell lines and preclinical models, translational data remain limited

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The latter may be particularly relevant in subpopulations of asthmatics given the marked clinical heterogeneity of the disorder

Notably, melatonin increases p53 expression through the PI3K/Akt/mTOR signaling pathway, which plays a significant role in tumor suppression