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Modulation of reactive oxygen species (ROS) in pancreatic cancer: insight into tumor growth suppression by the superoxide dismutases

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This premise is based on the notion that subzero temperatures in supercooled storage can substantially slow down metabolism to mitigate the metabolic storage lesion and thus extend storage time

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To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig