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Acknowledgements We acknowledge the DSFP contract, King Saud University, Riyadh, KSA (to SYA) and the Slovak Grant Agencies VEGA Project 1/0482/20 and APVV Project 19-0087

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Indeed, in clinical practice, metformin demonstrated a variety of beneficial effects on menstrual disorder, anovulation, androgen excess, insulin resistance, and cardiovascular risk, whereas its weight loss effect is often inconsistent and transient [21, 22]