Common ferroptosis inducers (FINs) act primarily on the System X c /GSH/GPX4 axis and can be roughly divided into four classes based on their targets: class-1 FINs such as erastin inhibit SLC7A11, class-2 FINs such as RSL3 and ML162 inhibit GPX4 enzyme activity, class-3 FINs such as FIN56 deplete GPX4 and CoQ10, and class-4 FINs induce lipid peroxidation (52)
Pavicic T, Korting HC
Ensure staff check and document BUDs at each administration and follow your SOPs
Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)
The most common Mounjaro side effects are: feeling sick (nausea) being sick (vomiting) diarrhoea stomach pain constipation low blood sugar (symptoms include headache, drowsiness, weakness, dizziness, hunger, confusion, irritability, sweating, fast heartbeat) Most of these side effects will go away once your body gets used to the medication you are taking