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Classic examples include native GLP-1, which has a plasma half-life of approximately 2 minutes and required continuous infusion in early studiesan impractical route for chronic therapyyet was subsequently transformed into a once-weekly therapeutic through lipidation and albumin-binding strategies ( Third, pleiotropic signaling that aligns with physiological function rather than nonspecific toxicity favors re-evaluation

34: 131420 Rodrguez-Segade S, de la Pea CA, Paz M, et al

Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster

Clinical practice

doi: 10.1016/0003-9861(91)90084-V 108 YamamotoTTakanoNIshiwataKOhmuraMNagahataYMatsuuraTet al