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Changes in Insulin Regimen Including Changes to Administration Site Changes in an insulin regimen (e.g., insulin strength, manufacturer, type, injection site, or method of administration) may affect glycemic control and predispose to hypoglycemia [see Warnings and Precautions (5.3)] or hyperglycemia

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Liraglutide was another agent in the class showing a similar mortality reduction but to a lesser degree compared to oral semaglutide

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In color the derating will be negligible