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2013;70(2):25976 Zhang Z and Wang FS

In addition, cells in mature biofilms exhibit altered gene expression patterns, with up-regulation of drug efflux pumps and stress-response pathways (heat-shock proteins, calcineurin signaling), metabolic shifts resulting in micro-niches (areas with hypoxia or nutrient limitation) that diminish activity from fungicidal drugs (Ramage et al., 2005

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