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Models were adjusted for age, gender, and the last recorded values of HbA1c, BMI, and LDL cholesterol before treatment initiation

Steven N, Abhinav V, Tony L, Daniel vL

Some research suggests that menopausal women taking hormone replacement therapy (HRT) may have better methylation patterns in menopause, possibly reducing cardiovascular disease risk

At higher supplemental doses (500 to 3000 mg daily), niacinamide can cause nausea, liver enzyme elevation, or glucose intolerance, but these effects are unlikely at the low doses used in compounded formulations