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The mechanism of action includes several key effects: they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the brain to promote satiety and reduce food intake

Both are FDA approved to treat type 2 diabetes, but people are now taking them off-label for a different purpose: to help shed stubborn pounds

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They usually present with painless rectal bleeding

60 However, in humans, early studies demonstrated that GLP-2 administration for five weeks increased spinal BMD in people with short bowel syndrome, 62 but had limited overall bone benefits