Injected subcutaneously, a peptide can yield a bioavailability of up to 50%, which is worlds above the sub-1% you might get from an orally ingested alternative.18 19 The reason for such a large disparity is that orally ingested peptides must pass through your digestive tract, where they can easily degrade, and peptide molecules are often too large to pass easily through your intestinal lining.19 Its true there are oral peptides that leverage absorption-enhancing technologies, but even with them youre getting maybe just a bit closer to 2% bioavailability little improvement over non-enhanced forms.20 Its also true that orobuccal administration (through the linings of the mouth) provides a much more bioavailable route than ingestion, but even through that route the relative absorption is less than half that of subcutaneous injection.37 Things being as they are, if you want to get the most out of your peptide therapy for weight loss, subcutaneous injection is the way to go at least until the technology improves enough to raise oral alternatives to the same level of absorptiveness
So perhaps its not surprising that a study published in JAMA earlier this week saw a similar effect in pregnant people
The peptide is commonly used in research exploring endocrine signaling pathways, receptor activation dynamics, and hormone regulation mechanisms
While research has confirmed their biological activity and therapeutic potential, clinical application is still largely in the early stages
Reviso tcnica: Gabriela Mieko, nutricionista esportiva do Espao Einstein de Reabilitao e Esporte do Hospital Israelita Albert Einstein
