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Interestingly, deletion of pU S 3 does not prevent the initial budding step but rather causes the accumulation of enveloped perinuclear virions in nuclear herniations, pointing to the dual role of the viral kinase in the nucleus and perinuclear space during viral egress 42,45,63

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they have achieved 7080% 5-year survival rates, however the treatment induces severe side effect

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