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Understanding your genetic peptide-pathway profile allows for dose optimization and potential compound switchingfor example, from semaglutide to tirzepatide or from injectable to oral formulationsbased on your predicted side-effect profile

In this situation, combination therapy shows unique advantages, CPT (an NRF2 inhibitor) (139), anti-angiogenic drugs (140), immune drugs (PD-1 inhibitors), etc

The proproliferative effects of GLP-1 RAs on gastrointestinal tissues have been questioned in preclinical studies, although their anti-inflammatory and metabolic properties suggest a protective role [40]

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If you're also taking insulin or sulfonylureas, discuss hypoglycaemia risk and monitoring