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J Neurol Neurosurg Psychiatry 65 : 446453

During signal transduction, the JAZ repressor protein, as a negative regulator, affects the transduction of JA signals by interacting with the MYC2 transcription factor [82]

Additionally, the body must rely on liver detoxification to get rid of it

In summary, GLP-1 receptor agonists regulate hepatic lipid metabolism in MASLD through activation of AMPK-mediated fatty acid -oxidation, suppressing lipogenesis-related gene expression, and enhancing lipid export and autophagy