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Common physical and psychological symptoms during the acute withdrawal phase of detox include digestive changes, muscle pain, anxiety, and mood swings, which can be managed with medication, hydration, nutrition, and supportive therapies

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Availability of data and materials The data that support the findings are available from the Exercise and Biochemical Nutritional Laboratory (EBNL) in the Department of Human Performance of Baylor University and the grant sponsor, being the Function Research Group of Kyowa Hakko Bio Co., Ltd