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In intestinal L cells, proglucagon is cleaved to the alternate products glicentin (169), glicentin-related pancreatic polypeptide (130), oxyntomodulin (3369), glucagon-like peptide 1 (72107 or 108), and glucagon-like peptide 2 (126158)

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Genetic non-response means the downstream biological pathways the medication targets are functioning differently at the variant level which dose adjustment alone may not fully address

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