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(For small-molecule drugs like semaglutide, at least seven years must have passed from its FDA approval date to be eligible for selection, and for drugs with multiple FDA approvals, CMS will use the earliest approval date to make this determination.) If that happens, a negotiated Medicare price would be available beginning in 2027

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Three of the primary antioxidant enzymes contained in mammalian cells that are thought to be necessary for life in all oxygen metabolizing cells 6 are superoxide dismutase (SOD), catalase, and a substrate specific peroxidase, glutathione peroxidase (GPx) (Fig