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Some studies have had promising results, but the overall evidence is not conclusive

Tirzepatide in Canada Health Canada approved Tirzepatide (Mounjaro) for type 2 diabetes in November 2022 and for chronic weight management in April 2024

Within this page, we will talk through a summary of key insights, with more detailed data an insights available in the linked sections below

Specifically, the gut microbiota acts as a metabolic bridge: it ferment dietary nutrients to produce bioactive metabolites (e.g., SCFAs, tryptophan derivatives), which signal to the brain via three pathways: 1

Gallbladder concerns: Retatrutide showed a 2.4% rate of gallbladder-related adverse events over 68 weeks