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3 Hepatocyte necrosis: apoptosis-inducing factor (AIF) and endonuclease G, along with other mitochondrial components, are released into the cytoplasm, causing chromatin condensation and DNA fragmentation

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Excessive free radicals without enough balancing Glutathione can harm the cell and cause oxidative stress

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While mitochondria produce ROS during oxidative phosphorylation, the ROS are appropriately eliminated by several antioxidants under normal physiological conditions