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It also underscores why replenishing glutathioneeither directly or through precursorsis a primary therapeutic target for neuroinflammation

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Interestingly, CR3 is also recognized in low MW (1,3)- - glucans, generated from high MW (1,3)- - glucans through the actions of macrophages and other cells

Increasing the amount of glutathione in your diet isnt always viable, especially as you age or if you have a medical issue that interferes with how glutathione is produced or used

Existing studies mostly focus on single pathways or cell types, lacking a comprehensive explanation of the systemic remodeling of immune-metabolic networks, especially the mechanisms of inter-organ metabolic-immune axes and metabolic crosstalk among different immune cell subsets remain unclear (Thenappan and Weir, 2024