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158 Cellular senescence is intricately involved in various physiological and pathological processes within the body, 159 exhibiting a dualistic role in tumorigenesis by both promoting and suppressing cancer

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Role of phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), and protein kinase c (PKC) in calcium signaling pathways linked to the (1)-adrenoceptor in resistance arteries

No oral or topical therapy has been shown to be efficacious when administered alone, but some evidence supports their use as part of a combination therapy regimen